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Antidepressants
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Antidepressants are often the first-choice medication for treating women whose severe premenstural syndrome (PMS) or premenstrual dysphoric disorder (PMDD) includes unbearable symptoms. These drugs are also known as selective seratonin reuptake inhibitors or SSRIs. An SSRI affects the brain's use of a chemical messenger (neurotransmitter) called serotonin. This change in seratonin use in your brain has been shown to improve physical and emotional PMS symptoms like depression, anxiety, hot flashes, and chronic pain.
How Effective are SSRIs?
Research shows SSRIs are very effective in relieving the emotional and physical PMS and PMDD symptoms for most women. SSRI therapy usually brings relief within a few days of starting medication and taking an SSRI only during the premenstrual phase appears to be as effective as continuous SSRI treatment.
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